The premise of our research is to develop chemical probes that enable novel bioanalytical methods, especially at single-cell resolution.
what's cooking now
- We implement chemical methods for assaying metabolites at the single-cell level. The goal is to expand the current arsenal of microfluidics-based multiplex single-cell metabolic assay technology.
- We establish non-genetic approaches to dynamically interrogate cell signaling activities at the single-cell level.
- We design and construct topologically complex multi-cyclic peptides for specific recognition of protein epitopes and small molecules. We also explore their potential applications in bioanalytical chemistry and catalysis.
- We develop special strategies to improve the currently available immuno-therapies.